Recent items from the news feeds of various BOINC projects.
The researchers welcome a new permanent team member.
View article · Tue, 13 Apr 2021 20:22:31 +0000
The researchers continue to publicize the project and work on making the data easy to share.
View article · Fri, 9 Apr 2021 14:55:23 +0000
MLC@Home has posted the Apr 8 2021 edition of its weekly "This Week In MLC@Home" newsletter!
Information on the 2021 BOINC workshop next week, where we'll present MLC and release our first paper!
Read the update and join the discussion here.
View article · Fri, 9 Apr 2021 01:28:09 +0000
The third challenge of the 2021 Series will be a 3-day challenge celebrating the 60th anniversary of Yuri Gagarin's history-making venture into outer space. The challenge will be offered on the WW application, beginning 11 April 18:00 UTC and ending 14 April 18:00 UTC. This is a relatively new subproject here at PrimeGrid, and there are currently no known Wall–Sun–Sun primes! You could be the first to find one! To participate in the Challenge, please select only the Wieferich and Wall-Sun-Sun Prime Search (WW) project in your PrimeGrid preferences section. Questions? Queries? Quips? Discuss on the forum thread for this challenge. Best of luck!
View article · Thu, 8 Apr 2021 15:32:42 +0000
We are updating the operating system on our servers on Thursday, April 8, beginning at 15:00 UTC.
View article · Wed, 7 Apr 2021 15:09:53 +0000
The software that powers OpenPandemics - COVID-19 has been adapted to use GPU power. This will not only help the researchers to screen more molecules, but also could help them study molecules that are more complex.
View article · Tue, 6 Apr 2021 17:20:00 +0000
On 02th of March, 3DpNKyXhViXrNkzNVoTcy7VQKmKS, a member of the team Gridcoin found the last prime for base S676.
The prime 607*676^544517+1 has 1.540.957 digits and entered the TOP5000 in Chris Caldwell's The Largest Known Primes Database.
View article · Sat, 3 Apr 2021 06:56:13 +0000
Опубликованы обработанные результаты за январь – март 2021 г.
Порция содержит 200007 КФ ОДЛК.
Processed results for January - March 2021 are published.
A portion contains 200007 CF ODLK.
View article · Fri, 2 Apr 2021 19:16:49 +0000
From April 2, 2021 to April 5, 2021 there will be temporary problems with access to the project.
These problems are related to the changes in infrastructure.
View article · Fri, 2 Apr 2021 15:05:23 +0000
on June 28-29 2021, there will be a scientific conference "ANTYCOVID-21: Computer science protecting human society against epidemics", in an online format, hosted in Poland. We aim to present a talk about SiDock@home and will be glad to see all of you as listeners. We also encourage you to submit own works if you participate in a covid-related research!
Paper submission 15 April
Notification of paper acceptance: 15 May
Final paper submission and registration: 30 May
Conference 28-29 June 2020
The papers should be submitted via Easychair
The submission may include long papers limited to 12 pages in Springer LaTex llncs format or short papers (up to 4 pages)
All questions about submissions may be emailed to antycovid21 at easychair.org
View article · Fri, 2 Apr 2021 11:27:23 +0000
Our database cluster is heavily loaded today, and LHC@home services time out from time to time. Our DBA is trying to fix this. Sorry for the trouble and happy crunching.
View article · Mon, 29 Mar 2021 16:43:57 +0000
Beta testing is in progress for GPU work units, which can help speed up the process of identifying potential treatments for COVID-19.
View article · Fri, 26 Mar 2021 18:11:38 +0000
Members of the MLC@Home community:
We have created a Discord server for MLC@Home!
Discord is a web-based chat application that, like similar services Slack and Mattermost, re-invents IRC but with less features. However, it does provide an accessible interface for everyone, and makes it easy to create new communities and bots to keeping things up to date. It provides for real-time text-based communication between the community. It compliments (but does not replace) the project web forums, and is, of course completely optional for participating in the project.
We chose Discord over other options since there is already a BOINC community project presence on Discord, and writing private bots is relatively easy. Originally this was created for personal use, as it is a single place to collect notifications for new forum posts, the twitter feed, GitLab CI updates, etc. But we're opening it to the larger community if there's interest.
We're still learning how to run a public Discord server so expect some growing pains.
The Discord server invite link is below if you'd like to join:
-- MLC@Home Admins
View article · Thu, 25 Mar 2021 20:22:36 +0000
We've been focused on several things recently, and TWIM Notes hasn't been a priority since there hasn't been too much to talk about and, frankly, they take a while to put together. Going forward, TWIM Notes will be intermittent for a few more weeks, but we aim to be back every week in about a month.
This won't be a full TWIM Notes, but here's a few tidbits of news:
* If you follow the progress on https://gitlab.com/mlcathome/mlds, you'll see that progress on v9.90 continues. We've successfully upgraded to PyTorch v1.8, and just today managed to *finally* get the client statically linked. That will allow us to drop appimage, makes the client a bit smaller overall, and should vastly help compatibility between linux releases. Hopefully the same can be done for windows, ARM, and CUDA/ROCM.
* You can follow v9.90 progress here: https://gitlab.com/mlcathome/mlds/-/milestones
* We've signed up to present at the 2021 BOINC Workshop next month, and will use that time to launch the paper and highlight the release of the datasets so far.
* We're setting up a MLC@Home discord server for real-time chat to compliment the forum and twitter, stay tuned for the invite when it goes live!
View article · Wed, 24 Mar 2021 02:39:49 +0000
SBG3 (OVH) infrastructure element of the iThena project was restored today.
The iThena tasks should slowly start functioning normally.
View article · Sun, 21 Mar 2021 20:09:42 +0000
Our fifth target is the E protein. We are emotionally attached to this protein because we explored its druggability in the early days of our project in the context of Covid.
At only 75 amino acids long, the envelope protein (E) is the smallest of the four structural proteins that make up the SARS-CoV-2 virus particle, and it is essential for the virus to infect cells. Data from other coronaviruses led researchers to suspect that groups of five E proteins form a pore that spans the lipid bilayer membrane of the virus. However, there was no direct evidence because the structural characterization of membrane-spanning proteins is difficult with the most commonly used techniques - X-ray crystallography and cryo-electron microscopy. Mei Hong's group at the Massachusetts Institute of Technology instead used nuclear magnetic resonance spectroscopy to solve the structure of the E protein and confirm pore formation (Nat. Struct. Mol. Biol. 2020, DOI: 10.1038/s41594-020-00536-8). The group also investigated how two drugs, amantadine, and hexamethylene amiloride, can bind to and block the pore. Although these drugs only bind weakly to the pore, the researchers say the new structural information could help in the development of drugs that target the virus.
In our HTVS, we will screen 1 billion of the small molecules to the pore of the E protein pentamer. We hope to find some nice molecules that can block the pore ;-)
View article · Fri, 19 Mar 2021 21:50:22 +0000
View article · Fri, 19 Mar 2021 11:53:09 +0000
The researchers continue lab testing on drug candidates that may be effective against proteins and other molecules that play key roles in certain childhood cancers.
View article · Thu, 18 Mar 2021 17:55:48 +0000
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