Posts by Sir LanDroid

InfoMessage
1) Message boards : Projects : SiDOCK@Home
Message 114243
Posted 11 Jul 2024 by Sir LanDroid
The next target for anlysis is Ebolavirus glycoprotein (GP).
...We hope that our computations will contribute to the fight against Ebola!
https://www.sidock.si/sidock/forum_thread.php?id=285#2284
2) Message boards : Projects : TN-Grid
Message 113711
Posted 2 Mar 2024 by Sir LanDroid
New experiment on Spinal muscular atrophy (SMA) from Mus musculus
We just started two experiments (gene expansion) on two different datasets (rnaseq, riboseq). There will be a total of about 140k workunits (2x tasks), each one relatively fast, distributed in batches. 2/13/24
If interested please follow the discussion here: https://gene.disi.unitn.it/test/forum_thread.php?id=384
However current WU status = 0 to send...
3) Message boards : Projects : SiDOCK@Home
Message 113462
Posted 27 Jan 2024 by Sir LanDroid
Dear all, we have obtained results for different targets of SARS-CoV-2. The computations continue, and we want to ask your opinion on the next target. You can vote for one of them until February 5th, 2024.

* SARS-CoV-2 main protease (3CLpro) further studies
This is a crucial therapeutic target against SARS-CoV-2. 3CLpro (cysteine protease; EC 3.4.22.69) in particular is crucial for the cleavage of coronavirus polyproteins to form mature non-structural proteins that are themselves essential for viral replication mechanisms. We still need much more research on this target towards new more potent inhibitors.

* Ebolavirus glycoprotein (GP)
Ebola virus is a dangerous pathogen to humans and this target could be a perfect study case for PPI-type drug design scenario. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion.

* Swine acute diarrhea syndrome coronavirus (SADS-CoV PLpro)
This target would enable us to study the design on multiple related viral targets. Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. The pathogen indicates towards host-jump potential.

Original thread with link to vote:
https://www.sidock.si/sidock/forum_thread.php?id=268
4) Message boards : Projects : Known potential evil applications of some BOINC projects?
Message 113222
Posted 4 Dec 2023 by Sir LanDroid
- Many years ago there was a password cracking project possibly up to no good. It was shut down probably because it relied on Rainbow Tables, which someone thought made the project gay.
- I'm not too sure about Prime Grid. It probably helps the NSA to some extent.
- The leaders of the SiDock project are from Russia and Slovenia so it's gotta be sketchy. <= Disclaimer / Joke: I don't believe this & crunch it.
- Einstein@Home calculates data for the next generation of nuke weaponry.
5) Message boards : Projects : DENIS Medical research
Message 112198
Posted 29 Jun 2023 by Sir LanDroid
Dear volunteers,
I am writing to update you on how the project is going and the results we are obtaining.

First of all, the optimization of the new model we are developing has already finished (the first one we released). Unfortunately the results have not been as expected. The optimization has worked very well and many markers have been improved, but one of the model issues that we are trying to fix has reappeared after the optimization. We think we understand where the problem is coming from and why it seemed like we fixed it, but really didn't. If we are right, this will require rethinking the model and starting over. Before starting again, we are testing various optimization settings to try to optimize the model without getting to the point where the problem reappears. We're not sure if it will work (this is science), but before we have to start over, we want to test this option.

On the other hand, some of you have already noticed that we are launching work in the Beta version. One of our pending projects was to use DENIS not only to improve the model we were developing, but also to try to improve other existing models. Let's start with this part of the project. For now, we will use the O'Hara and Rudy model, one of the most used in research. We have released the simulations in Beta version because we have never tested this model in DENIS before, but they will soon be released in HuVeMOp.

Finally, you may have noticed that we have run out of space a couple of times lately: the increase in the number of simulations requires more speed to get the results out and post-process them. We are working on further automating these processes in order to continue growing.

Thank you all very much for your support of the project and we will keep you informed of new developments.

Sincerely,
Jesus 6/20/23


Hmmmmm.....This might not turn out well....
6) Message boards : Projects : Einstein@Home
Message 111637
Posted 22 Apr 2023 by Sir LanDroid
Results from deep all-sky search on LIGO O3 data
The results of our all-sky search for continuous gravitational waves in public data from LIGO's third observing run (O3) have been published on the arXiv preprint server: Deep Einstein@Home all-sky search for continuous gravitational waves in LIGO O3 public data. The manuscript is currently in the peer-review process for publication in The Astrophysical Journal.
Link: https://arxiv.org/abs/2303.04109

...The search did not reveal any gravitational-wave signal. Based on this we draw conclusions about the population of neutron stars in our Galactic neighborhood. For example, within 100 parsecs (~330 light-years) around Earth there are no neutron stars rotating faster than 12,000 rpm with equatorial mountains larger than half a millimeter; otherwise we would have very likely detected their continuous gravitational waves.

4/20/23
https://einsteinathome.org/content/results-deep-all-sky-search-ligo-o3-data

Additional details at two links above.
"...there are no neutron stars rotating faster than 12,000 rpm with equatorial mountains larger than half a millimeter..." Wow the level of precision is astonishing.
7) Message boards : Projects : DENIS Medical research
Message 111540
Posted 11 Apr 2023 by Sir LanDroid
Dear volunteers,
We update you on the status of the project and how the simulations are going. In recent weeks the search algorithm has been improving the model very little. This indicates us that the optimization is close to be finished. Once this is complete we will pass to the validation phase which we will be done outside of DENIS (DENIS is not yet prepare for the required simulations).

4/11/23
https://denis.usj.es/denisathome/forum_thread.php?id=258

Click the link for more details including a graph of the error rate. They are now allowing the simulations to run with fewer constraints. Early results seem promising for improving this model of the electrical activity of cardiac cells. WUs seem to come in batches as they simulate, tweak the model, simulate...etc...
8) Message boards : Projects : Anything and Everything to do with (WCG) World Community Grid
Message 111490
Posted 3 Apr 2023 by Sir LanDroid
I just reported 30 WUs and received 1 new Covid task. πŸŽ‡πŸŽ†βœ¨πŸŽ‰
As reported earlier, Smashing Childhood Cancer tasks should also be available.
9) Message boards : Projects : Einstein@Home
Message 111481
Posted 2 Apr 2023 by Sir LanDroid
News about Einstein@Home searches for radio and gamma-ray pulsars

Dear Einstein@Home volunteers,
We'd like to update you about our searches for new neutron stars using data from radio telescopes and from the Fermi gamma-ray satellite. Thanks to you, Einstein@Home has already found 55 new radio pulsars and 39 new gamma-ray pulsars. With your continued support, we believe that many more will follow.
3/8/23
https://einsteinathome.org/content/news-about-einsteinhome-searches-radio-and-gamma-ray-pulsars

Check the link for more updates on the following topics.
All Arecibo data analyzed
Green Bank Telescope
MeerKAT
Post-processing of Arecibo data coming to Zooniverse
Finding gamma-ray pulsars in Fermi LAT data
10) Message boards : Projects : Anything and Everything to do with (WCG) World Community Grid
Message 111480
Posted 2 Apr 2023 by Sir LanDroid
We evaluated the possibility of starting download of processed WUs, while not sending new WUs out. It was determined that the risk of complications that might result from doing this with incomplete information available to our scheduler and BOINC or any other unforeseen issues is too high.

I was thinking it might help the overall situation if we set WCG to "No New Tasks." That way once the finished WUs start reporting, that traffic would not compete with new tasks downloading. Perhaps wait a few days after reporting to start downloading new WUs.

But after reading the above quote, it appears either that won't help much or WCG doesn't have information on that situation. However the pipeline is likely to be completely overloaded for while - seems like reducing total traffic for a brief period (by delaying DL of new tasks) would help the entire system recover more quickly? Waddya think?
11) Message boards : Projects : Anything and Everything to do with (WCG) World Community Grid
Message 111431
Posted 27 Mar 2023 by Sir LanDroid
...it will take about 74 hours.

Sounds good, but don't assume that is around the clock crunching. Spread over 8 hour days and no weekends or a standard 40 hour week, that could be 2 more weeks. So maybe 4/10?
12) Message boards : Projects : Anything and Everything to do with (WCG) World Community Grid
Message 111423
Posted 27 Mar 2023 by Sir LanDroid
C'mon folks we are slipping - there were zero complaints about WCG being down yesterday. This is unacceptable especially since they don't even work on weekends - we must do better.
Here's the first complaint today, can someone sign up for this afternoon? Ni! πŸ˜†
13) Message boards : Projects : Anything and Everything to do with (WCG) World Community Grid
Message 111411
Posted 24 Mar 2023 by Sir LanDroid
on a quick update, finally, /science filesystem is on the move to the new storage from the recovery storage unit. As of last night, after 3 hours, the new storage /science filesystem shows 1.4TB used. Assuming such average rate of file transfer, it will take about 74 hours. Hopefully, we will be able to restart BOINC from the new storage and finally put the failure behind us. We will keep you posted.

sincerely
igor
[Mar 24, 2023 11:18:51 AM]
https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,44980_offset,140


That's an update a few hours ago from someone who appears to be on Krembil / Jurisica team.
Here's another post looking ahead - doesn't make much sense and does not sound good...

as for the help - logistic is tricky considering we run from a different data centre - and of course we cannot give access to a broad group - but once we can at lest walk again, there are things we plan on our side, and other with the broader community. Briefly - we need to simplify the backend - at the moment, we often run into multi points of failure, instead of robustness. But - once we will be in such a position - we want to run hackathons - this can substantially help with optimizing code we run on the grid, and bring new projects. So far, nVidia is interested to discuss this further - as our plan is to bring more GPU projects. But - of course the backend has to be upgraded before that - as peak performance during GPU stress test in 2021 was around 16PFLOPS.

thank you all for your support
Igor
[Mar 24, 2023 12:47:48 PM]
(Same link as above)
14) Message boards : Projects : Anything and Everything to do with (WCG) World Community Grid
Message 111393
Posted 23 Mar 2023 by Sir LanDroid
Smashing Childhood Cancer has WUs teed up, waiting on the restart.
https://www.worldcommunitygrid.org/about_us/article.s?articleId=783
15) Message boards : Projects : World Community Grid has announced an extended outage from Feb 14 to April 22, 2022
Message 111223
Posted 8 Mar 2023 by Sir LanDroid
Another round of cascading hardware failures since about 3/1, replacing one thing and finding another problem. Here's the latest update from WCG - they're posting to Facebook & Twitter since their web site is down.

Hello everyone, hope you had a great weekend. We are still working with data centre to resolve the hardware failure so we can restart the storage, BOINC and website ASAP. We will post updates as we receive them. Thank you for your patience.

Update: Unfortunately, additional hardware problem on the storage server besides the RAID card are preventing us from restarting. Working with the data center on the alternative solutions.

Update #2: Unfortunately, the RAID controller was not the root cause of our storage system failure, the PCI bus failed. Data center is in the process of moving the disks to an alternate system and we will post updates as we progress. Once again, thank you for your patience.

March 6, 2023
https://www.facebook.com/worldcommunitygrid.org/
16) Message boards : Projects : DENIS Medical research
Message 111221
Posted 8 Mar 2023 by Sir LanDroid
Dear volunteers,
Allow me a brief message to update you on how the results are going after 15 more days of simulation. 5 iterations of the algorithm have already been completed. Of the 100 markers that we are using, 89 have already been achieved in the normal range (initially only 77 were). On the other hand, the distance between the average experimental behavior and the model has been reduced by 56.84%. Several parameters of the algorithm indicate that there is still room for improvement. We will keep you informed.

All the best,
JesΓΊs Carro https://twitter.com/InSilicoHeart
Universidad San Jorge https://www.usj.es/

March 8, 2023
Link to this update: https://denis.usj.es/denisathome/forum_thread.php?id=254
17) Message boards : Projects : SiDock@home
Message 111113
Posted 24 Feb 2023 by Sir LanDroid
They have been issuing a steady diet of very large WUs, taking several days to process on my old system. I7-3770 4 core/8 threads with 12G DDR3 ram.
Check how your system digests these large meals...
Ni!
18) Message boards : Projects : World Community Grid has announced an extended outage from Feb 14 to April 22, 2022
Message 110420
Posted 11 Nov 2022 by Sir LanDroid
Here's an update thread started Nov. 10. Some folks are seeing significant improvements.


https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,44700_offset,0
19) Message boards : Projects : World Community Grid has announced an extended outage from Feb 14 to April 22, 2022
Message 109709
Posted 27 Aug 2022 by Sir LanDroid
Excerpts from an update posted early this morning.

We have taken additional measures to increase the quantity of WUs we can send out, and we have been able to increase the quantity of WUs in flight at any given time. Volunteers should see this reflected on their devices now, and perhaps even over this past week.

We are also relieved to share that the hosting data centre has assigned additional personnel on site to resolve our networking issues, meaning a fix is imminent. We will share with you any further updates we receive from the data centre. The network fix will allow us to bring our remaining servers online, stabilizing and further increasing the WU supply. Thus, until we are able to deploy all dedicated servers, we must continuously adjust and monitor tasks scheduled in Aurora/Mesos to keep the tasks balanced and the workunits flowing, and so far this process is unduly intensive and sporadic.

...Last week, we mentioned that we have begun to investigate concerns over statistics, credit, streaks, and database dumps raised by volunteers. We will have an update on some of these issues next week. We also plan to release a more structured breakdown from the tech team similar to a CHANGELOG starting next week or the week after so that we can increase the frequency and clarity of updates.

https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,44273

[/quote]
20) Message boards : Projects : Project DENIS has restarted
Message 109658
Posted 18 Aug 2022 by Sir LanDroid
Status of the project
Hello!
I am writing this post to summarize a little news that we have had over the last month. As we have already commented on the forums, we detected a problem with the checkpoint files that caused many windows tasks to end with an invalid result. After several tests and several attempts we have managed to detect where the problem was and solve it. Due to this, we have implemented some of the improvements that we had planned for the checkpoint file. We have made it more robust. We have kept it as beta for quite a few days and it seems that the problem is fixed. We will continue to analyze how the program works, but the percentage of errors that we receive is more than reasonable in a project of these characteristics.

A special thanks to all of you who have been giving us feedback and helping us find the problem.

Today we have re-launched simulations in the NHuVe project. These tasks are no longer beta. We will inform you of the status of that project as we receive results. In the coming weeks we also plan to add tasks to the HuVeMOp project. With both projects working we hope to have a fairly stable flow of tasks.

On the other hand, we have been working on expanding the number of platforms and we have added in beta mode an application for ARM64 on linux (e.g. RaspberryPi), and ARM for Apple (for new Apple chips). We want to see how well they work. If all goes well, in the short term we could also consider expanding to Android.

All the best,
Jesus.

8/17/22
https://denis.usj.es/denisathome/
Next 20

Copyright © 2024 University of California.
Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation.