DENIS@home has launched some medical research on the Human ventricular cell model. The tasks are stable and work is continuously available.

OBTW ... badges are available.

Bill F

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In October 1969 I took an oath to support and defend the Constitution of the United States against all enemies, foreign and domestic;
There was no expiration date.

Dear volunteers,
Allow me a brief message to update you on how the results are going after 15 more days of simulation. 5 iterations of the algorithm have already been completed. Of the 100 markers that we are using, 89 have already been achieved in the normal range (initially only 77 were). On the other hand, the distance between the average experimental behavior and the model has been reduced by 56.84%. Several parameters of the algorithm indicate that there is still room for improvement. We will keep you informed.

All the best,
Jesús Carro https://twitter.com/InSilicoHeart
Universidad San Jorge https://www.usj.es/

March 8, 2023
Link to this update: https://denis.usj.es/denisathome/forum_thread.php?id=254

DENIS@home has launched some medical research on the Human ventricular cell model. The tasks are stable and work is continuously available.

OBTW ... badges are available.

Bill F

Got a whole bunch of tasks which as you say seem to be stable after posting elsewhere about having gotten a no work available message. Just seems a bit odd for me to be getting tasks that finish in 20 minutes compared to my usual.

Dear volunteers,
We update you on the status of the project and how the simulations are going. In recent weeks the search algorithm has been improving the model very little. This indicates us that the optimization is close to be finished. Once this is complete we will pass to the validation phase which we will be done outside of DENIS (DENIS is not yet prepare for the required simulations).

4/11/23
https://denis.usj.es/denisathome/forum_thread.php?id=258

Click the link for more details including a graph of the error rate. They are now allowing the simulations to run with fewer constraints. Early results seem promising for improving this model of the electrical activity of cardiac cells. WUs seem to come in batches as they simulate, tweak the model, simulate...etc...

Dear volunteers,
I am writing to update you on how the project is going and the results we are obtaining.

First of all, the optimization of the new model we are developing has already finished (the first one we released). Unfortunately the results have not been as expected. The optimization has worked very well and many markers have been improved, but one of the model issues that we are trying to fix has reappeared after the optimization. We think we understand where the problem is coming from and why it seemed like we fixed it, but really didn't. If we are right, this will require rethinking the model and starting over. Before starting again, we are testing various optimization settings to try to optimize the model without getting to the point where the problem reappears. We're not sure if it will work (this is science), but before we have to start over, we want to test this option.

On the other hand, some of you have already noticed that we are launching work in the Beta version. One of our pending projects was to use DENIS not only to improve the model we were developing, but also to try to improve other existing models. Let's start with this part of the project. For now, we will use the O'Hara and Rudy model, one of the most used in research. We have released the simulations in Beta version because we have never tested this model in DENIS before, but they will soon be released in HuVeMOp.

Finally, you may have noticed that we have run out of space a couple of times lately: the increase in the number of simulations requires more speed to get the results out and post-process them. We are working on further automating these processes in order to continue growing.

Thank you all very much for your support of the project and we will keep you informed of new developments.

Sincerely,
Jesus 6/20/23

Hmmmmm.....This might not turn out well....