Recent items from the news feeds of various BOINC projects.

[YAFU] Aliquot sequence 2912730 has terminated!!!

Aliquot sequence 2912730 has terminated!!!

View article · Sat, 18 May 2024 12:22:20 +0000

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[RakeSearch] Processing of the square # 38 completed

Dear participants, processing of the square # 38 is fully completed! The square:

0 1 2 3 4 5 6 7 8 9 A B
1 2 3 B 5 7 4 9 0 A 6 8
9 A 6 4 8 0 B 1 7 2 3 5
A 6 4 5 0 1 8 2 9 3 B 7
7 9 A 6 B 8 3 0 5 1 2 4
2 3 B 8 7 9 5 A 1 6 4 0
8 0 1 2 6 4 A 5 B 7 9 3
6 4 5 7 1 2 0 3 A B 8 9
5 7 9 A 3 B 2 8 4 0 1 6
4 5 7 9 2 3 1 B 6 8 0 A
B 8 0 1 A 6 9 4 3 5 7 2
3 B 8 0 9 A 7 6 2 4 5 1

has 541571814 orthogonal mates which puts it on the 26th place of the rating which include now 5711 positions.

Now "high part" of spectra of ODLS-12 looks like this (square # 38 marked by red):


Thank you for project attention, support and donation of CPU time!

View article · Fri, 17 May 2024 19:35:50 +0000

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[RakeSearch] Processing of the square # 37 completed

Dear participants, processing of the square # 37 is fully completed! The square:

0 1 2 3 4 5 6 7 8 9 A B
1 2 0 4 5 3 8 B 9 6 7 A
6 8 9 A 7 B 1 5 2 0 4 3
5 3 4 1 2 0 B 9 A 7 8 6
9 6 8 B A 7 0 4 1 2 3 5
B A 7 8 9 6 3 0 4 5 2 1
A 7 B 9 6 8 4 1 5 3 0 2
4 5 3 0 1 2 7 8 B A 6 9
7 B A 6 8 9 5 2 3 4 1 0
3 4 5 2 0 1 A 6 7 B 9 8
8 9 6 7 B A 2 3 0 1 5 4
2 0 1 5 3 4 9 A 6 8 B 7

has 527873490 orthogonal mates which puts it on the 28th place of the rating which include now 5684 positions.

Now "high part" of spectra of ODLS-12 looks like this (square # 37 marked by red):


Thank you for project attention, support and donation of CPU time!

View article · Fri, 17 May 2024 19:33:31 +0000

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[ODLK1] Electrical work 2

It seems that in my area electrical works are every month!

On 16/05/2024 from 9:00 to 13:00 there is no electrical power in the area again, so no connection to server (power supply should be able to carry the 4h of power off and still run the server, but without connection to internet).

Thanks

View article · Mon, 13 May 2024 17:17:53 +0000

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[World Community Grid] Research update from the MCM team (May 2024)

We continue to characterise lung cancer biomarkers identified in the MCM1 project. This update focuses on KLF5, a well-studied gene that has been implicated in several cancer types. KLF5 is a transcription factor, which is expressed across numerous organs and tissues.

View article · Mon, 13 May 2024 15:27:39 +0000

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[NFS@home] BOINC Pentathlon

Welcome BOINC Pentathlon participants. NFS@Home has been chosen for the Javelin Throw discipline starting May 10 at midnight UTC.

View article · Thu, 9 May 2024 16:31:16 +0000

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[ODLK1] Some issues

I just see today that the OS update of some days ago has stopped something in connection.

Now I reboot all to be sure new kernel were loaded.

Actually log seems good, so I hope that the Boinc activity is restored good.

Thanks

View article · Tue, 7 May 2024 19:15:16 +0000

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[YAFU] Aliquot sequence 2776776 has terminated!!!

View article · Tue, 7 May 2024 18:30:22 +0000

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[SRBase] server shutdown on 20.05.

In absence and rehab the project will be shutdown for a month to recover.

A full restart is planned after that if nothing else occured.

If you want to contact me in this time Iam still reached in discord forums.

Many thanks for understanding!

View article · Tue, 7 May 2024 17:51:13 +0000

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[YAFU] Aliquot sequence 2956992 has terminated!!!

Aliquot sequence 2956992 has terminated!!!

View article · Sat, 4 May 2024 07:49:25 +0000

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[GPUGrid.net] In-silico Binding Assay (ISBA/ACEMD3)

This is a message Adrià posted in our discord channel. Since he doesn't have an account in the GPUGRID forum I open the thread for him. If you want to be more up to date to the news related to this project and others please join our discord, we are usually more active there: https://discord.gg/dCMkcafPpX

Hello GPUGRID! Here Adrià. I'll be recovering the ACEMD3 application again, and sending new jobs of standard MD simulations (We've been testing it these past weeks to make sure it worked well for both Windows and Linux) The main goal of these new batch of simulations will be to validate further our capacity to predict the binding mode of ligands using simulations and adaptive sampling methods. Those of you that have been around for some time here might already be familiar with these simulations, such as the Benzamidin-Trypsin system (https://www.pnas.org/doi/abs/10.1073/pnas.1103547108) or the Dopamine D3 receptor with an antagonist ligand (https://www.nature.com/articles/s41598-018-19345-7#Ack1), which we were able to simulate thanks to GPUGRID and all your effort! Now, we are revisiting this method, which we call in-silico binding assay (ISBA). During drug discovery campaings, it's common that you know of ligands that bind to your target, but you don't know their binding mode, the exact conformation and structure that both the ligand and the protein have when bound. Knowing the binding mode is critical for further development of the molecule into a potent and usable drug. The most precise way of discovering the binding mode is with crystallization. However, that can take too much time or be directly impossible, depending on the protein. Therefore, we want to optimize and refine ISBA for binding mode prediction, so it can be usable during drug discovery projects. To summarize a bit our objectives, we want to predict binding modes for larger molecules than Benzamidin, with the same precision, but with less simulation time that was needed for the D3 receptor system. To do so, we'll be using the latest version of adaptive sampling that we developed, AdaptiveBandit (https://pubs.acs.org/doi/abs/10.1021/acs.jctc.0c00205). The objective of these new simulations I'll be sending will be to benchmark AdaptiveBandit in an ISBA scenario, improve the algorithm if required and fine-tune its hyperparameters. Let me know if there's any issue with the simulations. I'll be sending 100ns trajectories for the most part, divided in two steps.

View article · Thu, 2 May 2024 09:28:34 +0000

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[SRBase] project update

After returning from the hospital after a stroke, there has been a little progress with health. in 3 weeks a rehab is planned.

project updates so far:

- cert update
- gimps reserved results have all been reported
- server backup

still to be done...

2 results still need to be reported
RAM check as planned since 2 weeks

Thanks to everyone for all the well wishes, I wish everything would be better, maybe we'll be back at full speed in a month

View article · Wed, 1 May 2024 06:30:22 +0000

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[World Community Grid] ARP restart update

The ARP team is preparing to restart after the project was put on pause in December 2022. This article outlines the steps that we are taking in order to restart this project.

View article · Thu, 25 Apr 2024 15:09:54 +0000

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[PrimeGrid] GFN 19 Found!

On 13 April 2024, 03:42:53 UTC, PrimeGrid's Generalized Fermat Prime Search found the Mega Prime: 8630170^524288+1 The prime is 3,636,472 digits long and will enter “The Largest Known Primes Database” ranked 11th for Generalized Fermat primes and 83rd overall. The discovery was made by Antonio Lucendo (Trotador) of Spain using a dual CPU AMD EPYC 7B13 64-Core Processor @ 2.20GHz with 173GB RAM, running Ubuntu 22.04.3 LTS. This computer took about 4 hours, 45 minutes to complete the probable prime (PRP) test using Genefer22. Antonio Lucendo is a member of the XtremeSystems team. The PRP was confirmed prime on 14 April 2024 by an AMD Ryzen 9 7950X3D @ 4.2GHz, running Debian 12.5. This computer took about 26 hours, 11 minutes to complete the primality test using LLR. For more details, please see the official announcement.

View article · Tue, 23 Apr 2024 15:26:08 +0000

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[LHC@home] 20th BOINC Workshop May 29-31

The registration is now open for the 2024 BOINC Workshop -- this year in person, at CERN.

https://indico.cern.ch/event/1379525/overview

Please register if you plan to attend.

View article · Mon, 22 Apr 2024 09:21:39 +0000

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[YAFU] Aliquot sequence 28^95 has terminated!!!

Aliquot sequence 28^95 has terminated!!!

View article · Sun, 21 Apr 2024 06:57:42 +0000

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[ODLK1] Electrical work

On Thusday 23/4/2024 there are planned some electrical works in my area from 9:00 to 13:30 with power that probably will be tuned off too.

So the server could be not reachable during that times due to loss of internet connection.

View article · Sun, 21 Apr 2024 06:37:44 +0000

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[Gerasim@Home] Gerasim@home:

View article · Sat, 13 Apr 2024 02:19:00 +0000

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[Gerasim@Home] Gerasim@home:

View article · Fri, 12 Apr 2024 04:13:36 +0000

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[Gerasim@Home] Gerasim@home:

View article · Fri, 12 Apr 2024 04:13:34 +0000

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[RakeSearch] Processing of the square # 36 completed

Dear participants, processing of the square # 36 is fully completed! The square:

0 1 2 3 4 5 6 7 8 9 A B
1 2 0 4 5 3 8 B 9 6 7 A
6 8 9 A 7 B 1 5 2 0 4 3
5 3 4 1 2 0 B 9 A 7 8 6
9 6 8 B A 7 0 4 1 2 3 5
B A 7 8 9 6 3 0 4 5 2 1
A 7 B 9 6 8 4 1 5 3 0 2
4 5 3 0 1 2 7 8 B A 6 9
7 B A 6 8 9 5 2 3 4 1 0
3 4 5 2 0 1 A 6 7 B 9 8
8 9 6 7 B A 2 3 0 1 5 4
2 0 1 5 3 4 9 A 6 8 B 7

has 575323340 orthogonal mates which puts it on the 24th place of the rating which include now 5678 positions.

Now "high part" of spectra of ODLS-12 looks like this (square # 36 marked by red):


Thank you for project attention, support and donation of CPU time!

View article · Thu, 11 Apr 2024 15:00:24 +0000

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[RakeSearch] Processing of the square # 35 completed

Dear participants, processing of the square # 35 is fully completed! The square:

0 1 2 3 4 5 6 7 8 9 A B
1 2 0 4 5 3 8 9 A B 6 7
5 3 4 0 1 2 9 8 B A 7 6
B 7 9 8 A 6 5 1 3 2 4 0
A 6 8 9 B 7 1 5 2 3 0 4
6 8 A B 7 9 2 3 0 4 1 5
2 0 1 5 3 4 A B 6 7 8 9
4 5 3 2 0 1 7 6 9 8 B A
3 4 5 1 2 0 B A 7 6 9 8
9 B 7 6 8 A 4 0 5 1 3 2
7 9 B A 6 8 3 2 4 0 5 1
8 A 6 7 9 B 0 4 1 5 2 3

has 549717331 orthogonal mates which puts it on the 24th place of the rating which include now 5665 positions.

Now "high part" of spectra of ODLS-12 looks like this (square # 35 marked by red):


Thank you for project attention, support and donation of CPU time!

View article · Thu, 11 Apr 2024 14:57:52 +0000

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[PrimeGrid] JUICE's Birthday Challenge

From April 14^th 12:14:00 UTC to April 21^st 12:14:00 PrimeGrid will be running a 7 day challenge on the Riesel Problem project (TRP). Note the unusual start and end times! For more information, please see this forum thread.

View article · Wed, 10 Apr 2024 15:22:22 +0000

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